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RADIESSE® 1 Re-Awaken Skin from Within RADIESSE® is a highly researched & extensively studied regenerative biostimulator for improving skin quality.28 It utilizes an innovative particle technology which activates the body’s regenerative potential to firm and tighten your skin and reverses visible signs of ageing from within.28,31,32
RADIESSE® 3 Activate the skin‘s regenerative power RADIESSE is one of the most well-studied injectable biostimulators in Regenerative Aesthetics. With 98% patient satisfaction RADIESSE® delivers a triple effect.1,4,8,9,26,28,30,33 Firms Improves skin firmness, elasticity, and hydration. Delivering firmer, more elastic, and hydrated skin that looks healthier*, younger, and radiant which gradually progresses over time8,34,35 Tightens Regeneration results in smoother, tighter skin. See visibly smoother, tighter skin, while still maintaining authenticity4,34 Reverses Reverses visible signs of aging. For younger looking and healthier skin quality so patients can look their best at any age**1,8,33 Supported by over 20 years of advanced scientific and clinical research, RADIESSE uses advanced particle technology with 99% consistency to trigger a regenerative response. Its patented CaHA microspheres are uniquely engineered in material, shape, size, and texture to promote a non-inflammatory mechanism of action.1,2,4,9 * “Healthy-looking skin” is defined by regeneration of collagen I and III, elastin, proteoglycans, and angiogenesis. ** RADIESSE is not indicated for individuals younger than 18 years of age.
4 RADIESSE® How the aging cycle affects the skin From the age of 25 we lose 1% of collagen per year. As we age, both internal and external factors affect the skin’s natural aging process. While younger skin has a strong ability to repair itself, this capacity gradually declines over time. The skin functions as a balanced ecosystem, but aging disrupts this harmony, leading to the loss of essential components like collagen and elastin.13,14 Lifestyle choices such as poor diet, smoking, lack of sleep, excessive sun exposure, and rapid weight loss can accelerate skin aging. These habits contribute to a dull, tired appearance and increase visible signs of aging, including fine lines, wrinkles, and sagging skin.13,14 RADIESSE helps counteract these effects through its biostimulatory properties. It activates regenerative processes at the cellular level, gradually restoring collagen, elastin, and other vital skin components.This results in firmer, tighter skin with improved quality and a more youthful, balanced appearance.1, 9,13,14,23 Young skin Aged appearance After treatment
6 RADIESSE® What is happening under the skin as we age? THINNING SKIN • Starting at 25, our body produces fewer key structural components like collagen and elastin, leading to thinner and more fragile skin. • This results in fine lines, wrinkles, sagging and loss of suppleness. RADIESSE® meets each of these needs RADIESSE regenerates key components like collagen and elastin for thicker, firmer skin, reversing these visible signs of aging.8,9,34,35
RADIESSE® 7 FACIAL FAT LOST OR BONE RECESSION SHIFTING • When we’re young, facial fat is evenly distributed, giving a plump, smooth look. • From our late 30s - 40s, facial fat begins to shift and shrink—causing cheeks to sag and fat to gather around the chin and neck, creating a jowly appearance. • After age 40, facial bones start to lose density and reshape. • Affecting the structure and support of facial features and deepening wrinkles. By improving skin structure, RADIESSE supports underlying tissues, reversing visible signs of aging that can occur from fat loss.36 RADIESSE can help support facial areas that have experienced bone recession, adding structural support over resorbed bone.37
* RADIESSE is not indicated for individuals younger than 18 years of age. Please check your local regulatory approval.
RADIESSE® 9 Aging well fuels interest in regenerative biostimulation Patients seek more natural, subtle enhancements while maintaining authenticity. RADIESSE® serves diverse patient demographics open to using aesthetic injectables.3, 5-7 Versatile treatment options, tailored to help patients look their best at any age.*3, 5-7 RADIESSE® is suitable for - Proactive Aesthetic Care: Female & male patients aged 30s- 40s interested in reducing visible signs of aging and preserving a youthful look.1,5 - Regenerative Aesthetic Care: Female & male patients ranging 50s-60s + seeking to firm, tighten as well as contour, shape & define features.6, 26, 34, 38 82% 94% 62% Of consumers prefer natural, longer-lasting results—even if visible effects take 1–3 months. Of consumers find biostimulatory treat- ments appealing, viewing them as a safer, more natural way to age well. Of consumers are increasingly aware of regenerative aesthetics and link it to cellular renewal and a youthful appearance. DOF Global Consumer Survey – 2025. 2. DOF Global Consumer Survey - 2024
10 10 RADIESSE® RADIESSE® Who is the RADIESSE® patient?** Patient assessment characteristics * Physicians should score the degree of aging from 1 to 3 based on the Merz Aesthetics Scale (1-mild, 2-moderate, 3-severe). ** RADIESSE 1.5cc on-label 1:2 dilution for décolleté indication only. - Product availability dependent on country
12 12 RADIESSE® RADIESSE® Product Positioning Broad regenerative biostimulator for improving overall skin quality, texture and elasticity by progressive increase in collagen, elastin, and proteoglycans for a more youthful-looking appearance1,5,9,39 Targeted regenerative biostimulator for focused and concentrated collagen biostimulation for vertical lifting, sharpened contours and define areas of the lower face and jawline6, 33,38, 49
RADIESSE® RADIESSE® 13 13 Firms Tightens Stimulates collagen production to increase skin thickness & firmness1,21,23 Helps to increase elastin production to improve skin suppleness for a smoother appearance9,28 Reverses signs of aging For a healthier, more youthful look & overall skin quality improvement1,2,8,34 Firms Fine-tuning specific areas for targeted/focused improvements49 Reverses signs of aging Shape restoration due to facial fat loss in hollow cheeks, deep nasolabial folds6,33 Tightens Vertical lifting capacity due to high viscosity providing facial balance to jawline contour and definition. Repositioning of jowling or sagging6,38,50,51
14 RADIESSE® Indications for use RADIESSE® and RADIESSE® lidocaine offer flexibility & versatile use in the face and body. Now also offering more versatile treatment for regenerative biostimulation with RADIESSE® in a diluted form for the décolleté.5,6 RADIESSE® (+) RADIESSE® RADIESSE® 1:2 dilution Hands (replace loss of firmness & volume) Skin qua (enhance radian Jaw (contour & define)
kin quality radiance) Cheeks (restore shape) Nasolabial folds (restore shape) Jawline (contour & define) Sagging jowls (reposition & lift) Décolleté (smoother lines)
16 RADIESSE® How is RADIESSE® different from others? Biostimulators vs regenerative biostimulators. Within the biostimulator market, there is a subcategory. BIOSTIMULATORS Short-Term Effects Biostimulators deliver rapid effects by enhancing collagen production and skin hydration, offering varied short-term benefits and temporary enhancements.
RADIESSE® 17 REGENERATIVE BIOSTIMULATORS Long Term Benefits Regenerative biostimulators like RADIESSE® offer long-term benefits by maximizing and optimizing simulation within the body to restore functional elements of the skin tissue.1,39,40
18 RADIESSE® Scientifically proven, non-inflammatory action across all skin layers RADIESSE® provides immediately visible results that continue to gradually develop over time, providing a long-lasting* outcome.4,30,33,38 Before RADIESSE® Restoring wrinkle fibroblast contractility2,8,9 Immediate activation of dermal fibroblasts Epidermis Dermis Subcutis Direct contact with CaHA stimulate fibroblasts boost the regenerative response.12,13 Immediate lifting and contouring effect on signs of aging – smoothing of wrinkles and folds plus contouring.2,8,26,34 * Long-lasting refers to 12 months or more. Individual patient results may vary.
RADIESSE® 19 Improves structure of the skin at a cellular level Initial contact with inactivated fibroblasts Direct mechanical activation of fibroblasts CaHA Particles Fibroblast Activation of regenerative response • Collagen I and collagen III improve skin thickness, texture and tone21 • Elastin improves skin elasticity and firmness21 • Proteoglycans provide hydration and glow21 • Angiogenesis restores the skin’s vascular networks1,21 Natural restoration of the key components of the skin Regeneration of ECM components.1,8,9 Remodelling of the ECM**1,9,23 Epidermis Dermis Subcutis Restored firmness & skin thickness resulting in overall improved skin quality.2,8,9,34 Regeneration occurs by rebuild the skin structure at a cellular level by formation of collagen, elastin, proteoglycans & new blood vessels.1,9,23 ** ECM refers to the Extracellular Matrix
20 RADIESSE® Why does a non-inflammatory pathway matter? - Biostimulators trigger the body’s natural production of extracellular matrix (ECM) components like collagen and elastin. - Many competitors products work by relying on the body‘s immune system, which recognizes them as foreign. This immune response indirectly stimulates collagen and other protein production.13,41 RADIESSE® does not primarily rely on the body’s immune response to stimulate regeneration.31,42,43 - RADIESSE® contains biocompatible CaHA, utilizing ingredients (calcium & phosphate) that also naturally occur in the body. - The precise engineering of the RADIESSE® CaHA microsphere design promotes fibroblast adhesion and stimulates a primarily non-inflammatory regeneration of key ECM components.42,43 A potential advantage in promoting a non-inflammatory pathway is the consistency in the outcomes of a biostimulation treatment.42,43
RADIESSE® 21 Clinically proven regeneration: Particles matter RADIESSE® CaHA MICROSPHERES High-quality microspheres, , engineered with 99% consistency found in RADIESSE® are round, small, and smooth —with the unique shape, size, and texture to regenerate the skin promoting through a non-inflammatory pathway.1,4,9,24 PLLA PARTICLES PLLA particles are highly irregular flakes with many surface defects triggering an immune system response.45-47 COMPETITIVE CaHA MICROSPHERES Competitive CaHA microspheres are inconsistent in shape — some round, some highly irregular resulting in a higher propensity to trigger immune response.28
RADIESSE® 23 Fibroblasts matter Research confirms RADIESSE® improves skin structure and enhances skin quality for over a year*2,4 Fibroblast activation RADIESSE® improves fibroblast contractility, restoring function in both wrinkled and aged skin23 e c r o f e l i t c a r t n o c t s a b o r b F i l 1.4 x+5 1.2 x+5 1.0 x+5 0.8 x+5 0.6 x+5 0.4 x+5 0.2 x+5 ) N µ ( s n o t w e N o r c m i 0 4 8 12 16 20 24 Time (hours) Wrinkle fibroblasts + RADIESSE® Untreated wrinkle fibroblasts Contractile forces developed by human aged dermal fibroblasts in a GlaSbox® device incubated with RADIESSE®. Data are given as mean. CaHA stimulates fibroblasts within the ECM. = fibroblasts Cf = collagen fiber CaHA microsphere at 400× magnification, one month post-injection, CaHA is surrounded by fibroblasts—not macrophages.1 Actual Image Animated Image Still image from mechanism of action video. *Long-lasting results refer to 12 months or more. Individual patient results may vary.
24 RADIESSE® Results matter Collagen Production Collagen is a key protein in the skin, needed to provide structure and firmness.21 i n o s s e r p x e n e g a l l o c n a e M i n o s s e r p x e n e g a l l o c n a e M ) y t i s n e t n i i g n n a t s ( i ) y t i s n e t n i i g n n a t s ( i 6 5 4 3 2 1 0 6 5 4 3 2 1 0 ** * ** Study 1 Mean levels collagen type I and type III at baseline and after treatment with RADIESSE®.8 4.3 2.4 5.0 5.3 6.0 2.6 * p<0.05 ** p<0.00001 Baseline 4 months 7 months Type I Type III + 64% Study 2 64% sustained collagen I stimulation at 9 months for structural support.8 4.0 6.6 4 months 9 months
Collagen stained blue 1 month post-injection Collagen beginning to form around RADIESSE microspheres.48 Collagen stained blue 6 months post-injection Thick collagen has formed surrounding RADIESSE microspheres.48
26 RADIESSE® Elastin formation Elastin is a vital protein that enables skin maintain elasticity & flexibility.21 i n o s s e r p x e n i t s a e n a e M l ) y t i s n e t n i i g n n a t s ( i 6 5 4 3 2 1 0 + 85% 2.8 5.2 4 months 9 months Elastin (brown staining) before RADIESSE injection. 20x view of elastin in dermis prior to injection.9 Elastin (brown staining) after RADIESSE injection. 20x view of elastin in dermis 6 months post injection.9 RADIESSE® significantly increased elastin production by 85%, enhancing skin strength and elasticity for at least 9 months after injection8 Angiogenesis Density The process through which new blood vessels form from pre-existing vessels helps nourish the regenerated skin tissue.1,21 e r o c s n a e M 4 3 2 1 0 1.0 3.5 4 months 9 months RADIESSE® boosted neoangiogenesis, improving blood flow and nutrient supply to skin.21 Vessel density measured prior to injection Vessel density measured 4 months post injection
RADIESSE® 27 Proteoglycan Production Proteoglycans are proteins that support skin hydration and contribute to the overall structure of the skin.21 20x view of blue staining for proteoglycans before injection9 20x view of blue staining for proteoglycans 6 months after injection An increase in blue staining is easily seen around the rete ridges and papillary dermis.9 Source: Rovatti P, et al. Hyperdiluted Calcium Hydroxylapatite 1:2 for Mid and Lower Facial Skin Rejuvenation: Efficacy and Safety. Dermatologic Surgery 2020;46:e112-e117..
28 RADIESSE® Skin quality improvement: Results matter Treatment with RADIESSE® revitalizes key components of the skin, leading to significant improvements in skin thickness and improved skin elasticity.1,2,8,9,26 Skin thickness Thickness of the dermis at baseline and after treatment with RADIESSE®.8 * p<0.01 vs baseline ** p<0.0001 vs baseline Skin elasticity Skin elasticity at baseline and after treatment with RADIESSE®.8 ) m m ( h t p e D ) % , f U / a U ( y t i c i t s a e n k S i l 2400 2000 1600 1200 800 400 0 80 70 60 50 40 30 20 10 0 * ** 1462.3 1642.8 1865.9 Baseline 4 months 7 months + 10% + 15.7% 57.0 66.0 73.0 Baseline 4 months 7 months
Skin thickness is affected by age and can start thinning as early as the mid-twenties.13,14 Ultrasound scan of skin at baseline Ultrasound scan 7 months post injection Green area represents thickness of skin.8 Green area has widened showing thickening of skin post RADIESSE® injection.8
30 RADIESSE® What happens when you dilute* RADIESSE®? Undiluted RADIESSE® has a high viscosity which provides immediate volume and robust lifting capacity, especially in areas like the jawline. Delivers targeted regenerative biostimulation with minimal product spread.37,40 Before and after Patient injected 4.5ml Radiesse diluted with 0.9% sterile saline solution. Yearly maintenance injection of 3ml Radiesse diluted with 0.9% sterile saline solution, once per year. Before After - 6 months After - 3 years Diluted RADIESSE® - Spreads more easily, allowing more fibroblasts to interact with the microspheres and stimulate collagen and elastin via broad regenerative biostimulation.40 - While immediate results may not be visible, natural-looking improvements from biostimulation gradually continue to develop.40 *With RADIESSE, diluting 1:2 has been proven as the optimal ratios to maximize regenerative biostimulation effects in treating the decollete.*14
32 RADIESSE® Visible results with RADIESSE® Your patients will love the natural-looking effects. And a satisfied patient is often a loyal one who continues the treatment and recommends it to others. 95% of patients would recommend RADIESSE®27 94% of patience showed improved smile lines4 78 % of patients showed tighter skin34 23x More Collagen**,28 96% More Elastin**,28 48% improved Skin tickness26 With RADIESSE®, you can let your patients enjoy the joint benefits of immediate correction and long-term skin regeneration.1,3,29 **Disclaimer: Results are based on human tissue assessment comparing 6 months post Radiesse-treated skin vs. untreated skin (placebo)
RADIESSE® 33 After: 2 weeks Patient injected with 9ml of RADIESSE® in the cheeks and jawline. After: 4 weeks Patient treated with 1.5mL RADIESSE® + per side, in the jawline & nasolabial folds. After: immediately after Patient treated with 0.75mL RADIESSE® per hand. Before Before Before * No picture retouching has been done. Individual results may vary.
RADIESSE® 35 Proven safety & efficacy backed by scientific data Reasons to choose RADIESSE® - 20+ years of scientific and clinical experience with a well-established and favorable safety pro- file3,4,30 - 220+ peer-reviewed publications since 200528 - Available worldwide in over 85 countries28 - 98% patient satisfaction rate27 - 98% of patients willing to repeat treatment27 - 15 million+ syringes sold worldwide since 200528
36 RADIESSE® Re-Awaken Your Patients Skin from Within Product composition and characteristics5,6 RADIESSE® is proven to work with all Fitzpatrick skin types and is trusted by top HCPs around the world.*6,26 Composition - 70% Carboxymethylcellulose (CMC) - 30 % Calcium Hydroxylapatite (CaHA) - 70% Carboxymethylcellulose (CMC) - 30 % Calcium Hydroxylapatite (CaHA) - 0.3% Lidocaine Hydrochloride Product Formats - 1.5 ml / 3.0 ml - 1.5 ml * Body refers to Hands indication approved for RADIESSE & RADIESSE+ and Décolleté indication for RADIESSE 1:2 dilution
RADIESSE® 37 Merz Aesthetics® as a trusted partner Merz Aesthetics is a medical aesthetics business with a long history of empowering health care professionals, patients and employees to live every day with confidence. We aim to help people around the world look, feel and live like the best versions of themselves — however they define it. Clinically proven, its product portfolio includes injectables, devices and skin care treatments designed to meet each patient’s needs with high standards of safety and efficacy. Being family owned for more than 115 years. Merz Aesthetics is known for building unique connections with customers who feel like family. Merz Aesthetics’ global headquarters is in Raleigh, N.C., USA, with a commercial presence in 90 countries worldwide. It is also a part of Merz Group, which was founded in 1908 and is based in Frankfurt, Germany. Learn more at merzaesthetics.com All models and patients shown in this brochure are actual RADIESSE® patients.
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