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2 Intro UP CLOSE AND PERSONAL Natural-looking results, personal beauty journeys. Come closer: It’s about making your patients feel comfortable in their skin. Natural- looking results and balanced beauty – up close and personal. As an expert in the field of aesthetic medicine, beauty is your business. You encounter a wide range of people with different goals, desires, and ideals – all wanting a very personal beauty journey and natural-looking results that speak for themselves. It’s not always about perfection but about tailored aesthetic journeys, which enhance your unique beauty and invite you to take a closer look. All BELOTERO® products referred to in this brochure contain lidocaine, as BELOTERO® without lidocaine has been discontinued, with the exception of BELOTERO® Revive designed without lidocaine. For your information, BELOTERO® - lidocaine and -non lidocaine share the same product specifications with the key difference being the inclusion (or absence) of lidocaine.
4 Patients YOUR PATIENTS’ CONCERNS Natural-Looking results please According to a study, 43% fear a mask-like facial expression, and 41% unnatural-looking results.1 As gentle as possible 47% worry about potential nerve damage, while 33% are afraid the treatment could be painful.1 The time it takes to say yes From initial consideration to an actual treatment decision, patients take around seven to eight months.1 43% 47% 7–8 months Increasing interest and demand in filler treatments In most European markets, fillers are the most common aesthetic treatment.2 Once they decide to undergo treatment, the majority will have a procedure in mind, with lip augmentation ranking highly.3 Patients are becoming increasingly younger, with a rise in those under the age of 30 requesting injectable treatments.4 Online interest in noninvasive cosmetic procedures is increasing, and the Internet is where many people turn to for information.5
BELOTERO® 5 NATURAL-LOOKING RESULTS Before After Patient got injected with 3 ml of BELOTERO® Balance Lidocaine (marionette lines and vermillion 1.3 ml per side), 7 ml of BELOTERO® Volume Lidocaine (cheeks: 1.5 ml per side, chin: 3 ml, temples: 1 ml per side).* Now, it’s your turn to share your expertise, help your patients come closer to their aesthetic goals, and take them on a tailored treatment journey with the BELOTERO® hyaluronic acid dermal filler range. *The results shown are taken 14 days after treatment. No picture retouching has been done. Individual results may vary.
6 BELOTERO® Collection DISCOVER THE BELOTERO® COLLECTION For tailored treatment journeys The BELOTERO® collection offers you a range of different hyaluronic acid dermal fillers tailored to meet patients’ needs. Within the collection, there are products that can correct facial imbalances and volume loss, define contours, provide lift, volumi- ze, fill lines and wrinkles, and improve skin quality.6 Intentionally designed Each product in the portfolio has been intentionally designed to provide the optimal physical properties for a specific indication and target tissue. Tailored approach The BELOTERO® collection of HA fillers offers a wide range of treatment possibilities, to match patients needs, from smoothing and filling lines and wrinkles, including lip augmentation, to restoring facial volume, firming contours, and rehydrating the skin. Proven safety profile The BELOTERO® Collection has a well-established safety profile, demonstrated in both short- and long-term clinical assessment34.The rheology of BELOTERO® is tailored for specific injection depths and thus appropriate for specific treatment areas to avoid product palpability and visibility which means that patients are less likely to feel BELOTERO® in the skin with rare reported Tyndall effect.6, 35 Clinically proven The BELOTERO® collection has been in use in clinical practice since 2005, with more than 18 million syringes sold.36
BELOTERO® 7 Strong heritage The BELOTERO® Collection achieves seamless tissue integration and provides subtle, smooth results while respecting the natural contours of the face. With 20 years of clinical use, the BELOTERO® Collection and CPM technology is supported by evidence-based data, including over 150 publications worldwide and recognition through more than 10 international awards.36
8 BELOTERO® Collection TAILORED TO YOUR PATIENTS’ NEEDS The products in the BELOTERO® collection have been inten- tionally designed to be compatible with the tissues into which they are injected. This allows you to address a spectrum of different indications and injection depths, from skin revital- ization to deep volumizing.6 They can be used individually or simultaneously treating multiple areas, depending on the skin’s structural and functional needs aiming for predictable and harmonious results. Every patient is different, both in terms of their anatomy and in their acceptance of aesthetic interventions. The BELOTERO® collection addresses the full spectrum of facial aesthetic indi- cations, allowing you to treat patients as individuals with tai- lored treatment approaches.
Product REVIVE Treatment area HA concentration/cross-linking Needle size Volume Level of injection Revitalization of early-onset photodama- ged facial skin in the cheeks, as charac- terized by dehydration, loss of elasticity and firmness, and presence of superficial fine lines HA: 20 mg/ml, cross-linking level: + Glycerol 17.5 mg/ml 30 G½ 1 ml Mid to deep dermis SOFT Injection into the superficial to mid-dermis for treatment of perioral fine lines HA: 20 mg/ml, cross-linking level: ++ Also available with lidocaine: 0.3% 30 G½ 1 ml Superficial to mid-dermis BALANCE INTENSE Injection into superficial to mid-dermis for treatment of nasolabial folds, marionette lines, perioral lines, oral commissures. Also indicated for lip enhancement HA: 22.5 mg/ml, cross-linking level: +++ Also available with lidocaine: 0.3% 27 G½/ 30 G½ 1 ml Injection into the deep dermis for treat- ment of nasolabial folds and marionette lines. Also indicated lip enhancement HA: 25.5 mg/ml, cross-linking level: ++++ Also available with lidocaine: 0.3% 27 G½ 1 ml VOLUME Enhancement of the cheeks, the temples, the chin, or to treat severe nasolabial folds HA: 26 mg/ml, cross-linking level: +++++ Also available with lidocaine: 0.3% 27 G½/ 30 G½ 2 x 1 ml Superficial to mid-dermis, submucosal or subcutaneous for lip enhancement Deep dermis, submucosal or subcutaneous for lip enhancement Deep sub- cutaneous, Above periostea LIPS SHAPE LIPS CONTOUR lip enhancement, perioral lines, sever oral commissures HA: 25.5 mg/ml, cross-linking level: ++++ Also available with lidocaine: 0.3% 27 G 0.6 ml Deep dermis, Subcutaneous Lip contour Perio oral lines Oral commissure Lip enhancement HA: 22.5 mg/ml, cross-linking level: +++ Also available with lidocaine: 0.3% 27 G/ 30 G 0.6 ml Superficial to mid- dermis, submucosal or subcutaneous for lip enhancement B E L O T E R O ® 9
10 Technology AESTHETICS BORN FROM TECHNOLOGY Dynamic Cross-Linking Technology and Cohesive Polydensified Matrix BELOTERO® fillers are manufactured using the advanced Dynamic Cross-Linking Technology (DCLT), leading to tailored Cohesive Polydensified Matrix (CPM®) consisting of a mono- phasic gel with variable densities of cross-linked HA zones.16 Intentionally manufacturing products with different proportions of HA cross-linking density provides the range with the cohe- sivity required for seamless tissue integration in harmony with facial movements.6,17,18 Standard cross-linking Phase 1 Phase 2 Phase 3 Hyaluronic acid in its original form Linearization of the individual First hyaluronic acid (single chains, random coil structure). hyaluronic acid chains: cross-linking process with BDDE: the random coil structure untangles. a cellular monophasic gel emerges. Patented Dynamic Cross-Linking Technology (DCLT)16 Phase 4 Expansion of the gel that was created in the cross-linking process. Phase 5 Second cross-linking process, supplemented with additional non-cross-linked hyaluronic acid. Multiple density zones – how product behaves in skin after injection12
BELOTERO® 11 SEAMLESS TISSUE INTEGRATION For harmonious results Due to the optimal balance of its rheological properties, the BELOTERO® collection of fillers blends seamlessly into the skin and offers excellent seamless tissue integration with natural-looking and harmonious results.12 Each product has the ideal balance of cohesivity, elasticity, and plasticity to match the needs of the targeted layer of the skin: superficial, subcutaneous, and deep dermis or suprape- riosteal.16 Cohesivity For optimal integration into tissue Viscosity For staying power Malleability For malleability in accordance with requirements Elasticity Optimised tissue support Viscosity Cohesivity Elasticity Malleability REVIVE SOFT BALANCE INTENSE VOLUME LIPS SHAPE LIPS CONTOUR
12 Scientific evidence SEAMLESS DERMAL TISSUE INTEGRATION WELL SUPPORTED BY SCIENCE Extensive clinical evidence Continued clinical and scientific research ensures that the BELOTERO collection continues to expand and diversify and is supported by evidence-based data, summarized in a consensus publication.6 This provides advice on the selection of BELOTERO® products, administration techniques, and depths of injection for treatment indications in the upper, middle, and lower face. The aim is to assist physicians to provide seamless and natural-looking treatment results, enhanced safety, and patient satisfaction. The evidence base for BELOTERO® products continues to accumulate with data from three additional studies published in 2021. Treatments in a prospective, open-label, post-marketing study with BELOTERO® Volume showed safe and effective application in the midface, with improvements in temple and cheek fullness evident for up to 48 weeks.20 A high-resolution ultrasound study showed that superficial injection of BELOTERO® Lips Shape and Contour is associat- ed with homogenous tissue integration and improvements in lip architecture and volume for up to six months.21 Treatments in a randomized study showed safe and effective results of both single- and multiple-dose treatments with BELOTERO® Revive for revitalizing facial skin for up to nine months.22
Before and After BELOTERO® 13 RESULTS THAT SPEAK FOR THEMSELVES Before After Patient got injected with 1 ml of BELOTERO® Balance Lidocaine (perioral lines and upper lip: 1 ml), 4 ml of BELOTERO® Volume Lidocaine (cheeks: 2 ml per side), 0.6 ml of BELOTERO® Lips Shape. Before After Patient got injected with 1 ml of BELOTERO® Balance Lidocaine (lips: 1 ml), 1 ml of BELOTERO® Intense Lidocaine (nasolabial fold: 0.5 ml per side), 5 ml of BELOTERO® Volume Lidocaine (cheeks: 2.5 ml per side). The results shown are taken 14 days after treatment. No picture retouching has been done. Individual results may vary.
14 Doctor Information | Category Before After Patient got injected with 0.8 ml of BELOTERO® Intense Lido- caine (nasolabial fold: 0.2 ml per side), 2 ml of BELOTERO® Revive (cheeks: 1 ml per side). Before After Patient got injected with 1 ml of BELOTERO® Balance Lidocaine, 1 ml of BELOTERO® Intense Lidcaine (nasolabial fold: 0.2 ml per side), 3 ml of BELOTERO® Volume Lidocaine (cheeks: 1.5 ml per side), 0.6 ml of BELOTERO® Lips Contour. The results shown are taken 14 days after treatment. No picture retouching has been done. Individual results may vary.
BELOTERO® REVIVE BELOTERO® 15 BELOTERO® Revive is a beauty booster combining the power of hyaluronic acid (HA) with the skin-hydrating properties of added glycerol. Intended to improve skin hydration, radiance, elasticity, and firmness in the cheeks, it also fills fine and su- perficial facial lines to help redefine skin texture and provide patients with healthy-looking skin.13,23 For overall skin quality improvement, in the cheeks.13
16 Doctor Information | Rubrik BELOTERO® 16 The Revitalizer – for a glowing appearance13,23 • unique combination of HA and glycerol intended to revitalize the skin in the cheeks • Improves skin quality, hydration, elasticity, and firmness in the cheeks • Smooths fine lines and reduces skin redness Expert recommendation for skin revitalization6 Indication Product Skin revitalization (cheeks area) CPM-HA R Needle or cannula size 32G 4 mm needle or 30G needle Volume Injection plane Technique 0.02–0.05 ml/bolus; I ml/side (face): 0.02 ml per droplet Mid-to deep dermis BELOTERO ® Revive can be injected in the cheeks in a single session with a maximum volume of 3 mL, or in three injection sessions with a maximum volume of 2 mL per session that are spaced at least 4 weeks apart. These treatment regimens can be renewed at earliest after 6 months, resulting in a maximum annual dose of 12 ml Avoidance of complications Avoid large boluses with blanching technique
BELOTERO® REVIVE BELOTERO® 17 Skin glow booster based on science Two studies have assessed BELOTERO® Revive in patients with early signs of skin aging.13,22 Both studies demonstrated improvements in skin hydration for up to nine months after treat- ment, particularly in those with dry skin.13,22 Skin redness was reduced for up to nine months, improving overall skin tone and glow.13 Improvements in skin elasticity and firmness were also observed.13,22 BELOTERO® Revive safety was demonstrated in both single- and multiple-dose regimens.22 The Merz Aesthetics® BELOVE studies showed how BELOTERO® Revive improved skin elastic- ity, with an excellent safety profile and a generally lower level of injection site pain.13,22 Skin hydration Skin redness 12 11 10 9 8 7 6 5 4 3 2 1 0 20 10 0 -10 -20 -30 -40 -50 0 4 8 9 12 visit in week 24 28 36 0 4 8 9 12 visit in week 24 28 36 treatment visit Skin hydration – change after 3 treatments treatment visit Skin redness – change after 3 treatments Improvement of skin quality Up to nine months Of improved skin hydration and reduced skin redness13 Over 80% Of subjects were satisfied with the treatment at seven months13 90% Would recommend the product to friends13 100% All subjects showed an improved aesthetic outcome13 9 months 80% 100%
18 Doctor Information | Rubrik Results that speak for themselves Before After Revitalizing of the skin on the cheeks with 2 ml Belotero® Revive injections with three treatments, each 4 weeks apart. Individual results may vary.
BELOTERO® SOFT BELOTERO® 19 BELOTERO® Soft has the lowest viscosity within the collection and is used for smoothing fine and superficial lines such as perioral lines in patients with thin, delicate skin.6 The Fine Line Smoother 12 • Low elasticity and viscosity • Reduces the appearance of fine lines and wrinkles in the perioral area
BELOTERO® 21 ® BALANCE BELOTERO® Balance is a versatile filler with a wide range of indication areas6, allowing aesthetic experts to refine the face while retaining their patients’ natural look. It is also a favorable product for finishing touches. It is best used for the smoothing and filling of superficial lines, including perioral lines, nasolabial folds, marionette lines, and oral commissures.6 It is injected subdermally in patients with thin skin for example, in older patients. The versatile filler – for smoothing of facial lines14 • Balanced elasticity and viscosity • Refinement and filling of lines and wrinkles • Treatment of nasolabial folds, marionette lines, perioral lines, and oral commissures • Lip enhancement Significantly stronger smoothing of the skin surface with BELOTERO® Balance24 Cosmetic result (PRISMOS)* 0 -20 -40 -60 -80 -100 -120 l ® e n a y t s e R l e c n a a B ® O R E T O L E B 37.6 μm Change from baseline in μm (the larger the absolute value, the better the result) * PRIMOS: fringe projection method for 3D measurement of the skin surface
22 BELOTERO® BALANCE Proven safety and tolerability BELOTERO® Balance distributes evenly throughout the skin and allows for seamless skin integration.12 BELOTERO® ultrasonography images show a homogenous papule which is as dense as the surrounding tissue after injection into the superficial dermis, thereby indicating a good tissue integration in a diffuse manner. At day 15. BELOTERO® Balance appeared as a homogeneous papule in the dermis with no particles or leakage into the hypodermis.40 The orange circle represents the presence of the injected BELOTERO® Balance. Histological slides 15 days after injection40 Histological examination and comparison 0 and 15 days after injection indicating tolerability and tissue integration: • Day 0: Homogeneous distribution and integrated among the collagen fibres, with no inflamation. • Day 15: Similar findings; no inflammation at any time. BELOTERO® BALANCE BELOTERO® BALANCE Day 0 Day 5 VYCROSS GEL Day 0 VYCROSS GEL Day 15 • Day 0: Pools of variable size across dermis, mainly superficial and mid-dermis, no inflammation. • Day 15: Similar findings; with leak into superficial hypodermis; no inflammation observed. Compared to Vycross, which formed variable pools and leaked into the hypodermis, BELOTERO® BALANCE remained homogeneously integrated in the dermis with no leakage.
BELOTERO® 23 Unique blanching technique BELOTERO® is unique: It is administered with the blanching technique and only triggers a limited Tyndall effect. The blanching technique allows superficial injection in the dermis with BELOTERO® Soft or Balance for natural-looking results.8 Injection in superficial dermis, multiple punctures at intervals of 0.5 cm Blanching effect Before injection Blanching effect Approx. 7 minutes after injection
BELOTERO® 25 BELOTERO® Intense provides 2D architecture to provide the projection needed to smooth deep folds while maintaining facial structure. It has been shown to help fill deep wrinkles and folds as well as to restore and enhance soft tissue volume (e.g., contours of the face and lip volume). It can also be used to create sharp definition in areas with a lot of dynamic forces constantly in action such as the lips and marionette lines. The high cohesivity and viscosity of BELOTERO® Intense means that it requires more force to deform than other prod- ucts in the range, making it resistant to dynamic stress. This makes it perfect for lifting and contouring.6 The high elasticity under static compression of BELOTERO® Intense means that it is ideal for deep lines and wrinkles and that it stays where it has been injected.25 The Structural Lifter – for the lifting and filling of deep folds15 • High elasticity and viscosity • Structural enhancement, and lifting of deep wrinkles • Lip enhancement
26 Expert recommendation for marionette lines and sunken corners of the mouth6 Indication Product Marionette lines CPM-HA I Needle or cannula size 27G needle or 25 or 22G cannula Volume Injection plane Technique Up to 0.5 ml/ side; 0.01–0.02 ml/droplet 0.5 ml/side; 0.1 ml/thread Superficial dermis, subdermal Blanching technique, multiple punctures for superficial lines Entry point at prejowl sulcus and advancing towards oral commissure Avoidance of complications Avoid facial artery Indication Product Needle or cannula size Volume Injection plane Technique Sunken corners of mouth CPM-HA 27G needle 0.1 ml boluses; 0.05–0.2 ml/side Subdermal Considered tertiary areas of injection after all other deficits addressed Use remaining product to inject lateral lower and upper vermilion border Avoidance of complications Avoid facial artery
BELOTERO® 27 Results that speak for themselves Before After Patient got injected with 1 ml of Belotero® Balance Lidocaine (lips 1.0 ml), Before After Patient got injected with 0.8 ml of BELOTERO8 Intense Lidocaine (nasolabial fold: 0.2 ml per side) The results shown are taken 14 days after treatment. No picture retouching has been done. Individual results may vary.
28 BELOTERO® VOLUME The Volumizer – for volume enhancement and shaping6 • Restores the face’s former volume • Fills hollowed cheeks • Corrects signs of facial fat loss
BELOTERO® 29 ® VOLUME BELOTERO® Volume is specifically designed to correct imba- lances in the cheeks, temples, severe nasiolabial folds and chin, enhancing shapes in a refined yet visible way.37 The high malleability of BELOTERO® Volume allows you to mold and sculpt the product easily into the desired shape after injection to meet the individual needs of each patient.38 For a long-lasting volumizing effect that may last for up to 18 months after injection.28 Expert recommendation for chin augmentation6 Indication Product Chin projection CPM-HA V Needle or canulla size 22–25G cannula or 27–30G needle Volume Injection plane Technique 1–2 ml; 0.1–0.2 ml/bolus Epiperiosteal (cannula), periosteum upwards (needle) Inject pogonion using multilevel technique Avoidance of complications Use blunt-tip cannula with slow injection of multiple boluses
30 BELOTERO® VOLUME Efficacy and longevity The volumizing effect may last up to 18 months. Over this period, patients who received BELOTERO® Volume showed better aesthetic improvement compared to treatments with other brands.39 VOLUMETRIC ENHANCEMENT OVER TWO YEARS7 e n i l e s a b o t d e r a p m o c ) m m ( e g n a h c t h g e h n a e M i Fully cohesive 3.5 3.0 2.5 2.0 1.5 1.0 0.5 0.0 5 4 3 2 1 0 30 min 3 days 2 weeks 4 weeks 12 weeks 24 weeks Baseline A FILLER CPM-HA-V C FILLER H.I.C.E. B FILLER VYCROSS D FILLER NASHA CPM HA VYCROSS HA NASHA Cohesivity scores of different HA fillers on the GS Cohesivity Scale at three assay time points after needle extrusion 19 15 70 95 15 70 95 15 70 95 t = 15 sec t = 70 sec t = 95 sec Fully dispersed BELOTERO® Volume JUVÉDERM® Voluma RESTYLANE®
BELOTERO® 31 Tolerability BELOTERO® Volume demonstrates a high tolerability and safety profile from the time of injection and up to 18 months after injection.31 Proven patient satisfaction30,32 Clinical studies reveal that 94.4% of BELOTERO® Volume patients were satisfied with results immediately after injection as well as four weeks and three months post injection.38 Results that speak for themselves Before After Patient for injected with 1 ml of Belotero Volume (0.5 per side) in the nasolabial folds, 2 ml in the cheeks (1 per side) and 3 ml in the temples (1,5 per side) The results shown are taken 14 days after treatment. No picture retouching has been done. Individual results may vary.
32 BELOTERO® LIPS The Lip Enhancer and Definer – for harmonious lips21,33 • Designed with balanced elasticity and viscosity • Lip enhancement • Lip augmentation and restoration
BELOTERO® 33 ® BELOTERO® Lips Shape and Contour are complementary products that significantly enhance lip volume and re- duce perioral wrinkles. With a 93% patient satisfaction rate, BELOTERO® Lips Shape and Contour enhance volume and restore the outline of the lips for a natural-looking, more youthful appearance.21,33 Expert recommendation for harmonious lips6 Expert recommendation for lip contouring and philtral columns6 Indication Product Lip contouring CPM-HA LC Needle or cannula size 25G cannula or 30G needle† Volume Injection plane Technique <0.05 ml threads (needle); 0.1–0.2 ml/side (cannula) Superficial dermis Injection along vermilion border Entry point for the cannula just lateral to the oral commissure Avoidance of complications Avoid inferior and superior labial arteries; when volumizing, the safest Note Indication Product Needle or cannula size Volume Injection plane Technique zone is the subcutaneous plane of lateral upper and lower lip †Experts divided on whether a cannula or 30G needle should be used for the upper vermillion border Philtral columns CPM-HA LS 30G needle 0.05–0.1 ml/side in a retrograde linear thread Intradermal Retrograde linear threads from the base of the philtral column at the vermilion border Avoidance of complications Avoid inferior and superior labial arteries; when volumizing the safest zone is the subcutaneous plane of lateral upper and lower lip
34 BELOTERO® LIPS Seamless integration BELOTERO® Lips Contour integrates seamlessly into your patients’ skin tissue.21 A high-resolution ultrasound study of the lips showed complete product integration into the surrounding tissue at three months, which correlated with a significantly increased total lip surface area.21 BELOTERO® ultrasonography images show a homogenous papule which is as dense as the surrounding tissue after injection into the superficial dermis, thereby indicating a good tissue integration in a diffuse manner.9 Biphasic gel Monophasic monodensified gel HA filler papules are indicated by a red frame. BELOTERO® Lips Contour Monophasic polydensified gel Natural-looking results33 Physicians assessed the naturalness and evenness of the result with (A) CPM-HAL1 and (B) CPM-HAL2. ) % ( s t n e i t a P 100% 80% 60% 40% 20% 0 Naturalness Evenness Naturalness Evenness 22.7% 26.1% 23.7% 27.1% 8.7% 33.3% 13.0% 33,3% 75.3% 72.5% 72.2% 71.4% 87.0% 66.7% 87.0% 66.7% 2 weeks 4 months 2 weeks 4 months 2 weeks 4 months 2 weeks 4 months very good good satisfactory adequate The naturalness and evenness of the cosmetic result was assessed by most of the physicians with good to very good.
BELOTERO® 35 Lasting results for up to four months33* 70% of patients continued to experience visible lip improvements at four months.17 Lip volume Perioral wrinkles ) D S ± n a e m l ( s e a c S z r e M 4 3 2 1 0 * * ) Upper lip fullness * Lower lip fullness T N E M E V O R P M I D S ± n a e m l ( s e a c S z r e M 4 3 2 1 0 Oral commissures * Lip wrinkles * * T N E M E V O R P M I BL DOI 2 W 4 M BL DOI 2 W 4 M Upper lip fullness Lower lip fullness Lip wrinkles Oral commissures BL: baseline; DOI: date of injection; W: week; M: month; *p < 0.001 vs base line (BL). * The products injected were BELOTERO® Balance Lidocaine and BELOTERO® Intense Lidocaine, each in a 1 ml syringe. BELOTERO® Balance Lidocaine is the same formulation as BELOTERO® Lips Contour. BELOTERO® Intense Lidocaine is the same formulation as BELOTERO® Lips Shape. Results that speak for themselves Before After The results shown are taken 14 days after treatment. No picture retouching has been done. Individual results may vary.
38 For Men BELOTERO® FOR MEN It’s equally important to both women and men to be able to observe their reflection in the mirror with confidence and satisfaction. Yet women still account for a very high percentage of all the aesthetic medical procedures performed.19 But more and more men have the self-confidence to consider minimally invasive treatments, with a clear preference for correcting forehead and nasolabial lines and sculpting facial contours that have become soft. BELOTERO® products are suitable for both women and men, as HA is a vital component of the extracellular matrix of adult connective tissue.20 Aging skin differs between men and women. BELOTERO® suits both. The patient was injected with 2 ml of BELOTERO® Volume (nasolabial fold 0.5 ml per side, chin 1 ml), The results shown are taken 14 days after treat- ment. No picture retouching has been done. Individual results may vary. Before After
40 Facts HOW WE SUPPORT YOU 1 2 3 With training and education With long-term partnerships With proven products Training and education remain key to provide trusted patient satisfaction. We are committed to providing a range of training and education services tailored to your needs as an aesthetic expert – including hands-on training courses, on- line webinars and videos, and personal visits by our sales representatives. Merz Aesthetics® has developed into a trusted global partner in aesthetic medicine due to scientifically prov- en products such as the BELOTERO® range. We value long-term relationships with our partners in the field world- wide to fuel confidence in patients and redefine aesthetics together. Numerous studies have proven the effi- cacy of the BELOTERO® product range, while a variety of surveys demonstrate a high level of patient satisfaction, natural-looking and harmonious treat- ment results. Our complementary Merz Aesthetics® product portfolio offers tailored treatment solutions to your pa- tients to fulfill the needs of today’s di- verse patient demographic. Get in touch with your Merz Aesthetics® representative to learn more about our offering.
BELOTERO® 41 References Lorenc ZP et al. Plast Reconstr Surg. 2013;132:69S–76S. https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2005085329&_cid=P22-KU6OCI-88756-1. Last accessed 30 September 2021. 1. 2. Merz Consumer Study 2021. 3. Votto SS et al. Lip Augmentation. Oral Maxillofac Surg Clin North Am. 2021;33(2):185-195. 4. Rohrich R. https://www.plasticsurgery.org/news/blog/why-are-millennials-getting-botox-and-fillers-in-their-twenties. 5. Hopkins ZH et al. J Clin Aesthet Dermatol. 2020;13(1):28-31. 6. van Loghem J et al. Clin Cosmet Investig Dermatol. 2021;14:1175–1199. 7. Bezzola A, Micheels P. J Méd Esth et Chir Derm. 2005;Vol XXXII:11–20. 8. Micheels P et al. Plast Reconstr Surg. 2013;132(4 Suppl 2):59S-68S. 9. Micheels P et al. Dermatol Surg. 2012;38:1162–1169. 10. Taufig AZ et al. J Ästhet Chir. 2009;2:29–36. 11. Merz Aesthetics Data on File. 2021. 12. BELOTERO® Soft Lidocaine, Instructions for Use. Merz Aesthetics. 13. Hertz-Kleptow D et al. Clin Cosmet Investig Dermatol. 2019;12:563–572. 14. BELOTERO® Balance Lidocaine, Instructions for Use. Merz Aesthetics. 15. BELOTERO® Intense Lidocaine, Instructions for Use. Merz Aesthetics. 16. Patent family publication number: WO2005 / 08329. Biocompatible cross-linked gel. Available at: 17. Prasetyo AD et al. Clin Cosmet Investig Dermatol. 2016;9:257-280. 18. Micheels P et al. J Clin Aesthet Dermatol. 2017;10(1):29-36. 19. Sundaram H et al. Plast Reconstr Surg. 2015;136(4):678-686. 20. Pavicic T et al. Dermatol Surg. 2021;47(10):1359-1364. 21. Goldie K et al. J Drugs Dermatol. 2021;20(9):940-945. 22. Kerscher M et al. PRS Global Open. 2021;9:e3973. 23. BELOTERO® Revive. Instructions for Use. Merz Aesthetics. 2018 24. Prager W, Steinkraus V. Eur J Dermatol. 2010 Nov-Dec;20(6):748-52. 25. Gavard Molliard S, et al. J Mech Behav Biomed Mater. 2016 Aug;61:290-298. 26. Buntrock H, et al. Dermatol Surg. 2013 Jul;39(7):1097-105 27. Pavicic T. J Drugs Dermatol 2011;10:134–139 28. Prager W et al. J Drugs Dermatol. 2017;16(4):351-357. 29. Micheels P et al. Thérapeutiques en Dermato-Vénérologie, Sep.2014 (Mensuel 235, Cahier 3). 30. Micheels P et al. J Clin Aesthet Dermatol. 2015;8(3):28-34. 31. Kerscher M et al. Clin Cosmet Investig Dermatol. 2017;10:239-247. 32. Vandeputte J. J Clin Aesthet Dermatol. 2018;1(12):30-39. 33. Fischer TC et al. Facial Plast Surg. 2016;32(3):283-238. 34. Kühne U, Esmann J, von Heimburg D, Imhof M, Weissenberger P, Sattler G. Clin Cosmet Investig Dermatol. 2016;9:373-81 35. Michels 2019 36. Source: Merz, data on file 2025 37. BELOTERO® Volume Lidocaine, Instructions for Use. Merz Aesthetics 38. Gauglitz et al., “Cohesive Polydensified Matrix® Hyaluronic Acid Volumizer Injected for Cheek Augmentation Has Additional Positive Effect on 39. Hong et al., “Quantitative Evaluation of Volume Augmentation and Durational Changes in the Anteromedial Cheek with HA Fillers Using Three-Dimensional 40. Patrick Micheels,and al, Journal of clinical and aesthetic dermatology. 2017 Jan 1;10(1):29–36 Nasolabial Folds,” Clinical, Cosmetic and Investigational Dermatology, 2017 Measurement,” PRS Journal, 2022
2025, Merz Aesthetics® GmbH, Eckenheimer Landstrasse 100, 60318 Frankfurt, Germany.merzaesthetics. com.MERZ AESTHETICS and BELOTERO are trademarks and/or registered trademarks of Merz Pharma GmbH & Co. KGaA in the EU and/or certain other countries. All models in this brochure are actual MERZ AESTHETICS® patients. merzaesthetics.com 2 2 0 2 / x x x x x x x . r N - . t r A