MERZ Aesthetics

MERZ AESTHETICS®. Merz Aesthetics® celebrates the uniqueness in you and your patients. Together, we help the world look better, feel better, and live better. Changing the world together: Merz Aesthetics® has established a reputation as a reliable industry partner to health care profes- sionals around the world. For our partners and for us, aesthetic medicine is much more than optimizing appearance. At its core is the beauty that only emerges with a sense of confidence, uniqueness and self-assurance. We exist to fuel confidence in every person we touch – confidence in self and confidence in us. We are pioneering the industry with the way we see beauty in uniqueness and celebrate originality. We empower individuals in their personal quests to be their best selves – no matter what that means. Because every person has a unique brand of confidence. 3

Your practice. Your choices. Our partnership. INNOVATION ROOTED IN TRADITION Merz Aesthetics® has a long history as a trusted partner in the aesthetics industry. As part of Merz Group, a german company, family-owned since 1908, Merz Aesthetics® has become one of the leading global aesthetic companies. We support our partners not only with a diverse range of products, but also with state-of- the-art education, training, and additional services. SCIENCE AND EDUCATION Our products are unique; our attitude is different. We deliver trusted results through scientific evidence, education, and world-class manufac- turing. Our award-winning portfolio1 has been designed to meet the distinct consumer needs of today and tomorrow. With a focus on stringent scientific criteria, our research and development team aims to provide you with tailored support for your practice and business. BY YOUR SIDE As a health care professional, you are in the confidence business. Every day, you tap into your passion and expertise to deliver some- thing profoundly meaningful – and you look for partners that do the same. At Merz Aesthetics®, we believe that your success is our success. Each partnership with our customers is personal. It’s about listening, advising, supporting, and celebrating you. Together, we can fuel confidence and empower unique attitudes in aesthetics. ¹ RADIESSE® has been selected as a 2021 New Beauty Award winner. ULTHERAPY® wins for the 8th consecutive year the 2021 New Beauty award for the Best Non-surgical Skin Tightener. OUR PARTNERSHIP 5

Advancing science in medical aesthetics. Together. The health and well-being of your patients are at the heart of everything we do every day. All Merz Aesthetics® products comply with high standard of safety requirements and defined quality measurement processes. Patient safety and efficacy of our prod- ucts are critically important values our research and de velopment efforts are adhering to. Reduction of fine lines, rejuvenation, tightening, contouring, and volume enhancement: supported by a large number of clinical studies and scientific publications, our extensive product portfolio is setting new standards in science-based aesthetic medicine – delivering trusted results. 6 MERZ AESTHETICS®

Your passion – at the core of our services. Merz Aesthetics® is committed to safety, research and development, and training and education to give you confidence in our products today and the confidence to redefine aesthetic medicine of the future together. TRAINING AND EDUCATION We bring you insights and products that can help you guide your patients to make decisions that are right for their body and mind – for their entire being. We offer you an innovative mix of certified training options and practical training courses led by renowned experts in the field. Merz Aesthetics® has established a global leading standard in aesthetic medicine – focused on your needs at the core of all offerings. EXCHANGE WITH EXPERTS Merz Aesthetics® is committed to exchanging with industry experts through global scientific congress platforms and owned events dedicated to training and education, as well as scientific exchange. HIGHLY PERSONAL Merz Aesthetics® views each health care professional holistically and provides tailored service packages. With in-person visits, our highly qualified team can provide you with tailored support where you need it most: on-site at your practice. We celebrate the uniqueness in you and your patients because we are unique – built on science, originality, entrepreneurial spirit, and family. 10 MERZ AESTHETICS®

Your passion – personalized treatment journeys. Your patients are unique and require personalized treatment journeys. Merz Aesthetics® products can offer you a tailored solutions to fulfill the unique requirements of your patients and help them rediscover their unique beauty. A versatile biostimulator formulated with calcium hydroxylapatite microspheres. It is the only product that creates a scaffold to mechanically stimulate new collagen and elastin and has the versatility to also provide immediate lift and improvement of contours.¹–⁶ RADIESSE® delivers a triple effect: 1) vertical lifting ⁶–⁸ 2) sharpened contours ⁹–¹¹ 3) neocollagenesis. More than 11 Million patients treated globally.²⁸ A comprehensive collection of hyaluronic acid dermal fillers for smoothing and filling wrinkles, lip augmentation, restoring facial volumes, and rehydrating skin.¹⁶–¹⁸ Products deliver natural- looking results and seamless tissue integration through the unique CPM® Technology (Cohesive Polydensified Matrix).¹⁹–²¹ The collection includes BELOTERO® Volume, BELOTERO® Intense, BELOTERO® Balance, BELOTERO® Soft, BELOTERO® Revive, and BELOTERO® Lips Shape & Contour. More than 10 million patients treated globally.²⁸ Ultherapy PRIME is the evolution of Ultherapy, the Gold Standard in non-invasive lifting and skin tightening, leading the category with unmatched science and high patient satisfaction. ULTHERAPY® targets deep tissue planes for effective collagen synthesis and employs realtime visualization for customizable treatment – an integral step in optimizing patient outcomes.12–15 More than 3 million patients treated globally.29 12 MERZ AESTHETICS® The first highly purified botulinum toxin free of complexing proteins, precisely manufactured using the unique XTRACT TechnologyTM. Approved for the treatment of glabellar frown lines, hori- zontal forehead lines, and crow’s feet lines with high patient satisfaction.²²–²⁷ More than 10 million patients treated globally.²⁸

References. 1. Tzikas TL. Dermatol Surg. 2008;34 Suppl 1:S9-15. 2. Yutskovskaya Y, et al. J Drugs Dermatol. 2014;13(9):1047-1052. 3. Gonzalez N, et al. Dermatol Surg. 2019;45(4):547-551. 4. van Rozelaar L et al. Aesthet Surg J. 2014;34(1):118-132. 5. Bass LS, et al. Aesthetic Surgery J. 2010; 30(2):235-238. 6. Muti GF. J Drugs Dermatol. 2019;18(1):86-91. 7. Durkin A, et al. J Cosmet Dermatol. 2021 Feb;20(2):442-450. 8. Schachter D et al. J Drugs Dermatol. 2016;15(8):1005-10. 9. Dallara JM, et al. J Cosmet Dermatol. 2014;13(1):3-14. 10. Graivier MH et al. Plast Reconstr Surg. 2007;120(Suppl):55S. 11. Baspeyras M, et al. J Cosmet Dermatol. 2017;16(3):342-347. 12. Fabi SG, Joseph J, Sevi J, Green JB, Peterson JD. Optimizing patient outcomes by customizing treatment with microfocused ultrasound with visualization: gold standard consensus guidelines from an expert panel. J Drugs Dermatol. 2019;18(5):426-432. 13. Whitney ZB, Zito PM. Anatomy, skin, superficial cial musculoaponeurotic system (SMAS) fascia. In: StatPearls. Treasure Island, FL: StatPearls Publishing; 2019. https://www.ncbi.nlm.nih.gov/books/NBK519014/. Updated October 27, 2018. Accessed January 21, 2020. 14. Fabi SG, Massaki A, Eimpunth S, Pogoda J, Goldman MP. Evaluation of microfocused ultrasound with visualization for lifting, tightening, and wrinkle reduction of the décolletage. J Am Acad Dermatol. 2013;69(6):965-971. 15. Werschler WP, Werschler PS. Long-term efficacy of micro-focused ultrasound with visualization for lifting and tightening lax facial and neck skin using a customized vectoring treatment method. J Clin Aesthet Dermatol. 2016;9(2):27-33. 16. Fagien S, et al. Plast Reconstr Surg. 2019 Apr;143(4):707e-720e. 17. Rosamilia G, et al. J Cosmet Dermatol. 2020 Feb;19(2):312-320. 18. Fischer TC, et al. Facial Plast Surg. 2016 Jun;32(3):283-8. 19. Gavard Molliard S,et al. J Med Behav Biomed Mater. 2016;61:290-8. 20. Tran, C., et al. Dermatology, 2014;228(1):47-54. 21. Narins RS, et al. Dermatol Surg. 2010 Nov;36 Suppl 3:1800-8. 22. BOCOUTURE® (incobotulinumtoxinA) Summary of Product Characteristics. Merz Pharmaceuticals GmbH. 2020. 23. Prager W, et al. Clin Cosmet Investig Dermatol. 2012;5:53-58. 24. Frevert J. Drugs R D. 2010;10(2):67-73. 25. Frevert J. Drugs R D. 2015;15:1-9. 26. Dressler D. Eur J Neurol. 2012;19(3):385-389. 27. Kerscher, M et al. J Drugs Dermatol. 2019; 18(1): 52-57. 28. Data on file. Merz Pharmaceuticals GmbH. July 2021. 29. Data on file. Merz Aesthetics GmbH. August 2024. 14 MERZ AESTHETICS®

IMPORTANT SAFETY INFORMATION BOCOUTURE® 50 or 100 units, powder for solution for injection. Active substance: Botulinum toxin type A (150 kD), purified from Clostridium Botulinum cultures (Hall strain), free from complexing proteins. Prescription-only medicine! Qualitative and quantitative composition: One vial contains: 50 or 100 units of Botulinum toxin type A (150 kD), free from complexing proteins, human albumin, sucrose. Due to the differences in the potency assay, unit doses are not interchangeable with those for other Botulinum toxin type A preparations. Therapeutic indications: For temporary improvement in the appearance of upper facial lines in adults below 65 years when the severity of these lines has an important psychological impact for the patient: • moderate to severe vertical lines between the eyebrows seen at maximum frown (glabellar frown lines) and/or • moderate to severe lateral periorbital lines seen at maximum smile (crow’s feet lines) and/or • moderate to severe horizontal forehead lines seen at maximum contraction. Contraindications: Hypersensitivity to the active substance or to any of the excipients, generalised disorders of muscle activity (e.g. myasthenia gravis, Lambert-Eaton syndrome), infection or inflammation at the proposed injection site. Should not be used during pregnancy unless clearly necessary and not be used during breast-feeding. Undesirable effects: Undesirable effects usually occur within the first week after injection and are temporary in nature. They may be related to the active substance, the injection procedure, or both. Application-related: Localised pain, inflammation, paraesthesia, hypoaesthesia, tenderness, swelling, oedema, erythema, itching, localised infection, haematoma, bleeding, and/or bruising may be associated with the injection. Needle-related pain and/or anxiety may result in vasovagal responses, including transient symptomatic hypotension, nausea, tinnitus, and syncope. Undesirable effects of the substance class Botulinum toxin type A: Localised muscle weakness, blepharoptosis (possibly caused by the injection technique) are an expression of the pharmacological effect. Toxin spread: When treating other indications with Botulinum toxins, undesirable effects related to spread of toxin distant from the site of administration producing symptoms consistent with Botulinum toxin type A effects have been reported very rarely (excessive muscle weakness, dysphagia, and aspiration pneumonia with a fatal outcome in some cases). These cannot be completely ruled out with the use of BOCOUTURE®. Hypersensitivity reactions: Rare reports of serious and/or immediate hypersensitivity reactions including anaphylaxis, serum sickness, urticaria, soft tissue oedema, and dyspnoea, some of these reactions either following the administration of conventional Botulinum toxin type A complex alone or in combination with other agents known to cause similar reactions. The following undesirable effects were reported from clinical experience with BOCOUTURE®: Very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100). Vertical lines between the eyebrows seen at maximum frown (Glabellar Frown Lines): Common: Headache, Mephisto sign (lateral elevation of eyebrows); Uncommon: Bronchitis, nasopharyngitis, influenza-like illness, insomnia, eyelid oedema, eyelid ptosis, blurred vision, pruritus, skin nodule, brow ptosis, muscle twitching, muscle spasm, facial asymmetry (brow asymmetry), injection site haematoma, injection site pain, (local) tenderness, fatigue, discomfort (heavy feeling of eyelid/eyebrow), haematoma. Lateral periorbital lines seen at maximum smile (Crow’s Feet Lines): Common: Eyelid oedema, dry eye, injection site haematoma. Upper Facial Lines: Very common: Headache; Common: Hypoaesthesia, injection site haematoma, injection site pain, injection site erythema, discomfort (heavy feeling of the frontal area), eyelid ptosis, dry eye, brow ptosis, facial asymmetry, Mephisto sign (lateral elevation of eyebrows), nausea. Post-market- ing experience: Frequency not known: Hypersensitivity reactions like swelling, oedema (also distant from the injection site), erythema, pruritus, rash (localised and generalised), breathlessness, muscle atrophy, flu-like symptoms. Merz Pharmaceuticals GmbH, 60048 Frankfurt/Main, Germany. Date of revision of the text: February 2020. Further information is provided in the Summary of Product Characteristics and the Package Leaflet. BOCOUTURE® ia a registered trademark of Merz Pharma GmbH & Co.KGaA. RADIESSE® is a registered trademark of Merz North America, Inc. BELOTERO® is a registered trademark of Merz Pharma GmbH & Co. KGaA. For detailed product information please refer to the product instructions for use or reach out to your Merz Aesthetics representative. OUR PRODUCTS 15